It is hypothesized that the mechanism of action of octreotide correcting the blood pressure changes in all carcinoid crises is via its known inhibition of vasomotor product release from the tumor and blocking receptors for these substances Mechanism of Action Octreotide is an analog of the polypeptide hormone somatostatin. Octreotide acts on the somatostatin receptors, which couple to phospholipase C via inhibitory G proteins, and causes vascular smooth muscle contraction Octreotide exerts pharmacologic actions similar to those of the natural hormone somatostatin, but it is an even more potent inhibitor of growth hormone, glucagon, and insulin. 1,2 Once it presents in the systemic circulation, octreotide distributes and exhibits a 3-phase pharmacokinetic profile. 2-
part of the antidiarrhoeal action of octreotide is due to its effects on active electrolyte transport mechanisms by normal epithelial cells of the small intestine. Correspondence to: Dr J. Fordtran, Baylor University Medical Center, 2nd carcinoid syndrome, VIPoma and idiopathic diarrhoea, 770 C. HO¨ GENAUER et al Octreotide is a long-acting drug with pharmacologic activities that mimic those of the natural hormone, somatostatin, which inhibits the secretion of growth hormone. 8 Additionally, it is used for the treatment of acromegaly and symptoms arising from various tumors, including carcinoid tumors and vasoactive intestinal tumors (VIPomas). 8 In the.
Uses for Octreotide Carcinoid Tumors. When immediate-release injection is used in combination with telotristat etiprate for carcinoid syndrome diarrhea, administer immediate-release injection ≥30 minutes following administration of telotristat etiprate. and has a longer plasma half-life and duration of action relative to somatostatin octreotide in the prevention of complications related to pancreatic surgery (8). Patients were randomized to receive either octreotide 100 mcg subcutaneously every 8 hours stating at least 1 hour prior to surgery vs. matched placebo. The primary endpoint was the difference in postoperative complications includin Rubin J, Ajani J, Schirmer W, et al. Octreotide acetate long-acting formulation versus open-label subcutaneous octreotide acetate in malignant carcinoid syndrome. J Clin Oncol 1999; 17:600. Strosberg J, Weber J, Feldman M, et al. Above-Label Doses of Octreotide-LAR in Patients With Metastatic Small Intestinal Carcinoid Tumors Octreotide acetate injection is indicated for the symptomatic treatment of patients with metastatic carcinoid tumors where it suppresses or inhibits the severe diarrhea and flushing episodes associated with the disease
Sandostatin LAR Depot works by blocking the production of a number of hormones that can lead to severe diarrhea and flushing associated with carcinoid syndrome. Your doctor will identify if Sandostatin LAR Depot is right for you based on your response to, and how well you tolerate, 2 weeks of treatment with Sandostatin® (octreotide acetate. Octreotide is a synthetic version of somatostatin (a somatostatin analogue) and slows down the production of hormones. This helps to control the symptoms of carcinoid syndrome and slow down the growth of the cancer. Some of the symptoms you may have with carcinoid syndrome include flushing of the skin, diarrhoea and tummy (abdominal) pain Octreotide has been associated with sinus bradycardia, cardiac arrhythmias, QT prolongation, and conduction abnormalities in adult acromegalic and carcinoid syndrome patients. Other ECG changes observed included QT prolongation, axis shifts, early repolarization, low voltage, R/S transition, and early R wave progression These functional effects of SST provide the rationale for the use of SST analogs in various GI and non-GI endocrine disorders such as carcinoid syndrome, islet cell tumors, β-islet cell hyperplasia (nesidioblastosis), and acromegaly.4, 5 In addition, SST and octreotide can induce vasoconstriction of the splanchnic vessels, thereby reducing.
Mechanism : Octreotide exerts pharmacologic actions similar to the natural hormone, somatostatin. It is an even more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Like somatostatin, it also suppresses LH response to GnRH, decreases splanchnic blood flow, and inhibits release of serotonin, gastrin, vasoactive. Mechanism of action . SOMATOSTATIN is a key regulatory peptide of lower GI function - overall, it: . decreases intestinal fluid secretion; has dose dependent effects on GI motility:. low doses stimulate motility; high doses inhibit motility; has a short half-life (3 minutes) that limits its use as a pharmaceutical agent ; O CTREOTIDE is a synthetic analogue of SOMATOSTATIN, with a t½ of 1.5. Octreotide significantly decreases the levels of growth hormone and IGF-I (somatomedin C) in patients with acromegaly. Other actions of octreotide include suppression of thyroid stimulating hormone (TSH) release, inhibition of gallbladder contractility, and the secretion of bile. The FDA approved octreotide acetate in October 1988 Sandostatin ® LAR Depot (octreotide acetate) for injectable suspension is indicated for patients in whom initial treatment with immediate-release Sandostatin ® (octreotide acetate) Injection has been shown to be effective and tolerated for. Long-term treatment of the severe diarrhea and flushing episodes associated with metastatic carcinoid.
However, with Sandostatin LAR Depot 40 mg once a month, the incidence of new cholelithiasis in this pediatric population (33%) was higher than that seen in other adults indications such as acromegaly (22%) or malignant carcinoid syndrome (24%), where Sandostatin LAR Depot was 10 to 30 mg once a month This test comes back positive and an oral glucose load confirms the diagnosis of acromegaly. He is started on octreotide while he awaits imaging evaluation of his brain. Introduction. Drugs. octreotide. Mechanism of action. octreotide is a somatostatin analog. inhibits secretion of splanchnic vasodilatory hormones. growth hormone Mechanism of action in Chylothorax: Not clearly known; Postulated - Effect of Octreotide on GI Hormonal secretion and reduction in splanchnic blood flow reduces chyle flow through thoracic duct and thus, results in decrease in pleural collection of chyle; Licensed uses in USA: Treatment of Acromegaly; Carcinoid syndrome leading to diarrhoea and.
. It has also been used for the cessation of upper gastrointestinal bleeding [ 20 ] and to correct refractory hypoglycemia caused by sulfonylurea overdoses [ 21. Mechanism of Action of Octreotide. Octreotide is a potent synthetic octapeptide analogue of Somatostatin. The drug exerts it`s action by inhibiting the secretion of Growth hormone (GH), Thyroid stimulating hormone (TSH), Prolactin in pituitary; Insulin and glucagons in pancreas, and all gastrointestinal secretions including gastrin and HCl Octreotide therapy may be used to reduce fistula output in doses of 100 to 250 mcg subcutaneously every 8 hours. If a clinically significant reduction in fistula output is not evident within 5 - 8 days, octreotide therapy should be discontinued. • Level 3 Octreotide does not reduce time to fistula closure or closure rat Octreotide, a somatostatin analog, acts by inhibiting secretion of glucagon, a splanchnic vasodilator, and is a direct mesenteric vasoconstrictor.107 However, the effect of octreotide in patients with cirrhosis is dampened by antagonistic effects of local nitric oxide release,108 and octreotide alone has limited benefit in hepatorenal syndrome.
Glatstein M, et al. Octreotide for the treatment of sulfonylurea poisoning. Clinical Toxicology . 2012;50:795-804. Objectives: • Describe the statistics and characteristics of sulfonylurea poisonings. • Explain the mechanisms of action of andoctreotideasanantidote. • Explain the mechanism of sulfonylurea‐induce Octreotide has been reported to cause delayed gastric emptying, ileus, and both hypoglycemia and hyperglycemia. Nausea, pain at the injection site, elevation of liver enzymes, chest pain, emesis, headache, dizziness, fatigue, and flushing have been reported to occur in association with octreotide therapy ( 3,17,20 ) Octreotide long-acting injection is used to control acromegaly, carcinoid tumors, and VIP-omas in people who have been successfully treated with octreotide injection but prefer to receive injections less often. Octreotide injection is in a class of medications called octapeptides. It works by decreasing the amounts of certain natural substances. Octreotide contains the active moiety of somatostatin, and is several times more active than the endogenous hormone. Major Indications The major indications for octreotide use are not things we would treat in the ED. For example, it is used for chronic treatment of acromegaly, carcinoid tumor, and VIPomas First, a single dose of octreotide may take an hour to be effective, and the antidote activity only lasts for about eight hours. One may see hypoglycemia prior to the peak action of octreotide. Such was observed in a few patients in this study. Check the glucose again within 20 to 30 minutes of dextrose reversal
Octreotide is a synthetic long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.Octreotide is a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin.Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow, and. Mechanism of Action A peptide that mimics endogenous somatostatin. Somatostatin is released by the pancreas, pyloric antrum, and duodenum and inhibits Growth Gormone, Gastrin, Vasoactive intestinal peptide (VIP), Gastrin, Serotonin, and decreases Insulin like growth factor-1 (IGF-1), serotonin and it decreases splanchnic blood flow
Octreotide is a widely used synthetic somatostatin analogue that significantly improves the management of neuroendocrine tumours (NETs). Octreotide acts through somatostatin receptors (SSTRs). However, the molecular mechanisms leading to successful disease control or symptom management, especially when SSTRs levels are low, are largely unknown Octreotide has two formulations. For purposes of clarity, trade names will be used for discussion. Sandostatin ® is a short acting version and Sandostatin LAR ® is a long acting version. Sandostatin ® is given by subcutaneous injection (S.C. - the layer of tissue between the skin and the muscle). It may be necessary to take the shot several. Octreotide. A 50-year-old woman presents to her dermatologist for a rash of 1 week duration. She is noted to have erosions with crusting of the advancing edge, glossitis, and angular cheilitis. Her dermatologist notes that this rash is consistent with necrolytic migratory erythema, a condition seen in patients with glucagonomas Lheureux PE, Zahir S, Penaloza A, Gris M. Bench-to-bedside review: Antidotal treatment of sulfonylurea-induced hypoglycaemia with octreotide. Crit Care. 2005;9(6):543-9. PMC1414034
Octreotide. Somatostatin and its synthetic analogue octreotide (Sandostatin, SMS 201-995) have been used with short-term success in patients with dumping syndrome, but the long-term efficacy of octreotide is much less favorable. They exert a strong inhibitory effect on the release of insulin and several gut-derived hormones Neuroendocrine tumors overexpress somatostatin receptors, which serve as important and unique therapeutic targets for well-differentiated advanced disease. This overexpression is a well-established finding in gastroenteropancreatic neuroendocrine tumors which has guided new medical therapies in the administration of somatostatin analogs, both cold, particularly octreotide and lanreotide. Octreotide is also indicated for acromegalic patients unfit or unwilling to undergo surgery, or in the interim period until radiotherapy becomes fully effective. Relief of symptoms associated with functional gastro-entero-pancreatic (GEP) endocrine tumours, e.g. carcinoid tumours with features of the carcinoid syndrome (see section 5.1)
12.1 Mechanism of Action . 5 WARNINGS AND PRECAUTIONS . 12.2 Pharmacodynamics 5.1 Risk from Radiation Exposure. 12.3 Pharmacokinetics 5.2 . Myelosuppression. 13 NONCLINICAL TOXICOLOGY . 5.3 Secondary Myelodysplastic Syndrome and Leukemia. 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility 5. Metabolic syndrome (hyperglycemia and hypertriglyceridemia) Octreotide Mechanism of Action. Carcinoid tumor (ileal tumor with hepatic metastasis that secretes 5-HT causing secretory diarrhea flushing and wheezing) Insulinoma: fasting hypoglycemia due to excess insuli 19626 Background: Symptom of bowel obstruction are common and serious complications in terminal advanced cancer patients. Mechanisms of bowel obstructions include intraabdominal carcinomatosis, drug-induced intestinal immobility and intraluminal obstruction. Octreotide inhibits the release of the several gastrointestinal hormones thereby reducing GI tract secretion, and increase the GI tract. Octreotide is a long-acting analog of somatostatin. It inhibits the release of many endocrine peptides including insulin and glucagon. In addition, it inhibits the release of gastric acid. Because glucagon is a vasodilator, octreotide indirectly decreases splanchic blood flow by its action inhibiting the release of glucagon Somatostatin, also known as growth hormone-inhibiting hormone (GHIH) or by several other names, is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones. Somatostatin inhibits insulin and glucagon secretion
Octreotide is a potent inhibitor of growth hormone, glucagon, and insulin. It also suppresses gastrointestinal hormones including gastrin, motilin, secretin, and pancreatic polypeptide as well as decreasing splanchnic blood flow. Although the exact mechanism of action of Octreotide in chyle leaks is not well defined, it is attrib Octreotide is used to treat severe watery diarrhea and sudden reddening of the face and neck caused by certain types of tumors (e.g., carcinoid tumors, vasoactive intestinal peptide tumors) that. A randomised double-blind trial, in which octreotide LAR at 10, 20 and 30 mg every 4 weeks was compared with open-label s.c. octreotide every 8 h for the treatment of carcinoid syndrome, showed that the efficacy of both treatment arms was the same once plasma octreotide steady-state concentrations were achieved (Rubin et al. 1999). This study. Somatostatin (Octreotide) Mechanism of action octapeptide that mimics naturally occurring somatostatin, which is a potent inhibitor of growth hormone, glucagon, and insulin ; Clinical use acromegaly and gigantism; bleeding esophageal varices ; carcinoid syndrome ; gastrinoma ; glucagonoma ; Adverse effects headache ; hypothyroidis
The recent NETTER-1 phase III randomized trial of 177 Lu-DOTATATE vs. high-dose Octreotide LAR in patients with inoperable, progressive, midgut carcinoid tumors identified that 177 Lu-octreotate significantly improves PFS (PFS not reached vs. 8.4 months; hazard ratio 0.21, with a 79% reduction of the risk of progression) Octreotide is a widely used synthetic somatostatin analogue that significantly improves the management of neuroendocrine tumours (NETs). Octreotide acts through somatostatin receptors (SSTRs).However, the molecular mechanisms leading to successful disease control or symptom management, especially when SSTRs levels are low, are largely unknown. We provide novel insights into how octreotide. . indigestion. itching. dizziness. temporary redness of face and neck. headache. an abnormal stool color. ineffective painful straining of stool or urine. generalized weakness In patients with carcinoid syndrome, octreotide's ability to inhibit serotonin secretion results in decreased flushing, diarrhea, and wheezing, as well as reduced urinary excretion of 5-hydroxyindoleacetic acid (5-HIAA), the primary metabolite of serotonin Octreotide (Chemical Classification) Synthetic Octapeptide 2 Octreotide (Mechanism of Action) A potent growth hormone similar to somatostatin 3 Ocreotid
Both octreotide and midodrine have been tried alone or in combination in HRS with some beneficial effects. Oral midodrine, an alpha-adrenergic receptor agonist, causes vascular smooth muscle vasoconstriction, and subcutaneous octreotide, a long-acting somatostatin analogue, which is used to reduce portal hypertension after variceal hemorrhage Sandostatin ® LAR ® (octreotide) is a somatostatin analog. As such, its effects in the body are similar to those of the naturally occurring hormone, except that Sandostatin ® LAR ® remains active much longer than somatostatin. 1. Octreotide suppresses secretion of growth hormone (GH), and in many cases suppresses insulin-like growth hormone-1 (IGF-1) (somatomedin C). Seo et al, 2014. In terms of mortality and re-bleeding rates, there seem to be no difference between terlipressin, somatotatin and octreotide. Hepatorenal syndrome. Israelsen et al, 2015 meta-analysis. terlipressin is more effective than placebo, and equal with noradrenaline in efficacy. Terlipressin reduces mortality from Type 1 HRS
Hepatorenal Syndrome: Pathophysiology and Management. In the late 19th century, reports by Frerichs (1861) and Flint (1863) noted an association among advanced liver disease, ascites, and oliguric renal failure in the absence of significant renal histologic changes ( 1 ). Almost 100 yr later, in a seminal article by Hecker and Sherlock ( 2. Symptoms: Episodic hyperadrenergic spells; pain (headache), pressure (hypertension), perspiration, palpitations (tachycardia), and pallor. Lab Values: Urinary VMA. Octreotide 1982, Synthesized at Sandoz Labs Long acting analog of somatostatin Treatment for: acromegaly, pituitary adenomas pancreatic islet cell tumors, carcinoid tumors, portal hypertension, esophageal varcies, secretory diarrhea www.sandostatin.com Octreotide Mechanism of Action Mechanism of Action of PRRT (Peptide Receptor Radionuclide Therapy) Kwekkeboom DJ et al. HematolOncolClin N Am 2016;30:179-91. The radiolabeled SSAs are internalized, and the breakdown products of the radiolabeled peptides are stored in lysosomes, thus enabling a long irradiation of tumor cells. 177Lu-DOTATATE is both a β-emitter and γ-emitte Octreotide - mechanism of action: long-acting somatostatin analogue, stimulates small bowel motility: Dose and duration of octreotide ttt (Sc) 5 SSc patients pre- and post-ttt: 50 μg × 4 weeks Metal detector test: drug had no effect on GE, small bowel or colonic transit in patients vs. BsL: Folwaczny et al. 12
Octreotide may extend survival in hepatocellular carcinoma (HCC). Forty-one per cent of HCCs have high-affinity somatostatin receptors. We aimed to determine the feasibility, safety, and activity. Routine care for chylothorax in neonate includes either conservative or surgical approaches. Octreotide, a somatostatin analogue, has been used for the management of patients with refractory chylothorax not responding to conservative management. To assess the efficacy and safety of octreotide in the treatment of chylothorax in neonates What is octreotide injection, and how does it work (mechanism of action)? Octreotide acetate is an injectable medicine that is very similar to the hormone somatostatin, which is naturally produced in the body that has several effects including inhibition of the release of hormones. Octreotide works in a similar fashion as somatostatin, but is degraded more slowly and is a stronger inhibitor of. Prophylaxis against carcinoid crisis should be performed prior to surgical or locoregional interventions using adequate doses of somatostatin analogues. AntiproliferativeTherapy Octreotide Mechanism of Action. Susini C, Buscail L.Ann Oncol. 2006;17:1733-1742 An octreotide scan is used to evaluate the neuroendocrine system and involves three to four visits to the nuclear medicine department. Procedure On your first visit, the nuclear medicine technologist will review your health information and then inject a small amount of radioactive tracer into a vein in your arm
Endoscopic banding of varices is preferred over injection sclerotherapy. At the same time, IV octreotide (a synthetic analog of somatostatin, which may also be used) should be given. Octreotide increases splanchnic vascular resistance by inhibiting the release of splanchnic vasodilator hormones (eg, glucagon, vasoactive intestinal peptide). The. Octreotide is the pharmacologic agent of choice in acute variceal bleeding and is used in conjunction with endoscopic therapy. [15, 47, 48] This agent is a synthetic analogue of somatostatin that. Mechanism of action of Octreotide. Disposition:. Patient needs to be admitted to the ICU in the setting of Sulfonylurea overdose. Serum glucose should be monitored frequently (every hour) with treatment of dextrose and octreotide and 16-24 hours after their cessation The mechanism of action is still not completely understood but appears to involve Motor dysfunction of the small bowel and colon in patients with the carcinoid syndrome and diarrhea. N Engl J Med In eight healthy volunteers and five patients with diarrhea-predominant irritable bowel syndrome, octreotide increased the threshold to rectal.
Treatment of carcinoid syndrome: Definition. Octreotide (somatostatin analogues) Term. Rapid-acting insulins (3) Octreotide (mechanism, use, toxicity) Definition. Somatostatin analog; used to treat VIPoma and carcinoid syndrome: Increases GABA channel action; first-line for simple, complex, and tonic-clonic seizures in children; P450. nervousness. nightmares. redness of the face, neck, arms and occasionally, upper chest. seizures. shakiness. slurred speech. unusual tiredness or weakness. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine Hepatorenal Syndrome: A New Era. Hepatology. 2015 Jan 16. doi: 10.1002/hep.27709. Terlipressin plus albumin versus midodrine and octreotide plus albumin in the treatment of hepatorenal syndrome: A randomized trial Somatostatin analogs inhibit the secretion of hormones involved in vasodilation. Octreotide is a synthetic octapeptide. Compared with somatostatin, octreotide has similar pharmacologic actions with greater potency and longer duration of action. In the US, octreotide is used off-label for the management of variceal hemorrhage Drug-mon is an idea to make memorising drug names easier by associating drug names to a picture. You might have guessed that this is inspired from Pokemon (m..
The initial mechanism in the genesis of portal hypertension is an increase in vascular resistance that can occur at any level within the portal venous system. Portal hypertension is therefore classified as prehepatic (portal or splenic vein thrombosis); intrahepatic (cirrhosis), and posthepatic (Budd-Chiari syndrome) Ondansetron is a drug given to prevent and treat nausea and vomiting. This lesson will review its mechanism of action, adverse drug reactions, and contraindications Octreotide, a somatostatin analog, acts by inhibiting secretion of glucagon, a splanchnic vasodilator, and is a direct mesenteric vasoconstrictor.107 However, the effect of octreotide in patients with cirrhosis is dampened by antagonistic effects of local nitric oxide release,108 and octreotide alone has limited benefit in hepatorenal syndrome
Radioactive materials are really to be handled with care not with fear . Some of the proton- neutron combinations are not stable, they have excess energy which is constantly redi The mechanism in cirrhosis is thought to be portal hypertension resulting in high pressures in the splanchnic lymphatic vessels. This causes rupture of lymphatics and leakage of chylous fluid in the peritoneal space. Chylothorax is usually exudative but is transudative in the setting of cirrhosis, nephrotic syndrome and heart failure Conestat alfa is a recombinant human C1 esterase inhibitor, developed by Pharming Group NV for the treatment of hereditary angioedema (HAE). The company is als OBJECTIVE— Berberine (BBR) activates AMP-activated protein kinase (AMPK) and improves insulin sensitivity in rodent models of insulin resistance. We investigated the mechanism of activation of AMPK by BBR and explored whether derivatization of BBR could improve its in vivo efficacy. RESEARCH DESIGN AND METHODS— AMPK phosphorylation was examined in L6 myotubes and LKB1 −/− cells, with. Octreotide Mechanism: somatostatin analog. Uses: acromegaly and other secretory tumors, given to reduce splanchnic blood flow in GI bleeding. Side effects: cholelithiasis, diarrhea, mild abdominal discomfort. Desmopressin diabetes insipidus / more ADH action, less vasoconstriction . Growth Hormon
mechanism of action Albumin is normally present in the blood and constitutes 50% to 60% of the plasma proteins and 80% to 85% of the oncotic pressure. Exogenously administered albumin increases the oncotic pressure of the intravascular system, pulling fluids from the interstitial space, thereby decreasing edema and increasing the circulating. The following should be memorized regarding systemic antifungals: mechanism of action, pharmacokinetics, effectiveness against fungi/antifungal spectrum of activity, clinical uses, ADRs and toxicity. Table 48.1 and frame text Liposomal amphotericin B are not test material. Table 48-2 only informatively The following should be memorized regarding systemic antifungals: mechanism of action, pharmacokinetics, effectiveness against fungi/antifungal spectrum of activity, clinical uses, ADRs and toxicity. Table 48.1 and framed text Liposomal amphotericin B are not exam material. Table 48-2 only informatively
Octreotide (Sandostatin) for Cancer: Side Effects, Dosages . Rxlist.com DA: 14 PA: 50 MOZ Rank: 91. Octreotide is used to treat severe watery diarrhea and sudden reddening of the face and neck caused by certain types of tumors (e.g., carcinoid tumors, vasoactive intestinal peptide tumors) that are found usually in the intestines and pancreas.The symptoms occur when these tumors make too much. Growth Hormone (Somatotropin) Growth hormone is a protein hormone of about 190 amino acids that is synthesized and secreted by cells called somatotrophs in the anterior pituitary. It is a major participant in control of several complex physiologic processes, including growth and metabolism Mechanism of action is the suppression of insulin secretion.[medical citation needed] Octreotide can reduce the intestinal... Octreotide helps in management of the fistula by reducing gastrointestinal secretions and inhibiting gastrointestinal motility and vasoactive intestinal peptide, reduce secretion of fluids by the intestine and. Octreotide is a prescription medication used to treat the symptoms of acromegaly, carcinoid tumors, and vasoactive intestinal peptide adenomas. Octreotide belongs to a class of drugs called octapeptides, which work by decreasing the amounts of certain natural substances Mechanism Of Action. Insulin-like growth factor-1 (IGF-1) is a key hormonal mediator on statural growth. Under normal circumstances, growth hormone (GH) binds to its receptor in the liver, and other tissues, and stimulates the synthesis/secretion of IGF-1 Octreotide injection is used to treat severe diarrhea and other symptoms that occur with certain intestinal tumors (eg, vasoactive intestinal peptide tumors or VIPomas) or metastatic carcinoid tumors (tumors that has already spread in the body)