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Leukoplakia histopathological features

Introduction: Leukoplakia (LKP) is defined as a white patch or plaque on the mucosa of oral cavity, vulva, vagina etc., which cannot be removed and cannot be clinically or microscopically explained by presence of a disease. LKP is included in the group of lesions with malignant potential. Microscopic characteristics: Basic microscopic characteristics of oral LKP include hyperkeratosis of ortho. The present study had the aim to describe the histopathological characteristics of subclinical hairy leukoplakia, as well as to carry out a comparative analysis between clinical and subclinical OHL. For that, 11 cases were analyzed--5 biopsies from patients who presented with the lesion and 6 samples from the borders of tongues obtained in. Association between histopathological features of dysplasia in oral leukoplakia and loss of heterozygosity We provide evidence that architectural and cellular changes in OL have different LOH patterns. We provide evidence that architectural and cellular changes in OL have different LOH patterns Leukoplakia is a clinical term signifying a white, plaque-like lesion occurring anywhere on the oral mucosa. It is generally a reaction to irritation, such as cigarette smoking or tobacco or areca (betel) nut chewing, as well as an early sign of human immunodeficiency virus (HIV) infection. It appears most commonly in men 50 to 70 years of age Objectives: To analyse the clinical and histopathological features of oral leukoplakia (OL) in the Sudan, and to identify the risk factors associated with dysplastic and malignant changes. Methods: Records of 117 cases with the diagnosis of OL at the Department of Oral Pathology in the period from 2010 to 2017 were reviewed. Results: Of the 117 cases included in this study, 30 cases (25.6%.

Video: [Histological characteristics of oral leukoplakia

Leukoplakia

Leukoplakia is a white plaque that cannot be removed by gentle scraping and for which no other etiology can be identified. Microscopically, leukoplakias exhibit hyperplasia of keratinocytes, as represented by hyperorthokeratosis, hyperparakeratosis, and/or acanthosis Histopathological features Epithelial proliferation (inflammatory/ reactive changes in epithelium) Epithelial Dysplasia hyphae in leukoplakic lesions 40. Histopathologically, a distinction can be made between dysplastic and non-dysplastic leukoplakia 41 The aim of this study was to assess the prevalence of oral leukoplakia (OL) in HIV-positive patients and to evaluate the clinical and histopathological features and the presence of Candida hyphae and viral infections (HSV 1, 2, HPV, EBV and CMV) by immunocytochemical methods using mono- or polyclonal antibodies. A total of 269 HIV-seropositive. leukoplakia is still contraversal, because the term leukoplakia alone is not a disease entity (it has no definite clinical and histopathological features), which makes the definition for such lesion a difficult task if not impossible. Therefore, it has been suggested that leukoplakia is an incorrect term since there is s Proliferative verrucous leukoplakia (PVL) is a chronic, aggressive oral mucosal condition with a poor long-term prognosis. It has no specific, defining microscopic characteristics and is a clinical rather than histological diagnosis

[Oral hairy leukoplakia: histopathologic features of

  1. Oral leukoplakia (OL) manifests as patches that are bright white and sharply defined. The surfaces of the patches are slightly raised above the surrounding mucosa. Individuals with OL are not..
  2. The most important clinical characteristics of these entities are shown in Table 2. 11 Oral leukoplakia should also be differentiated from benign alveolar ridge keratosis, characterized by a whitish plaque in the gingival region of the maxillary or mandibular alveolar ridge and probably of traumatic or frictional origin
  3. Vulvar leukoplakia is not a histological diagnosis and involves several diseases. Most commonly, these are vulvar lichen sclerosus and squamous cell hyperplasia of the vulva. These two conditions have similar aetiology, clinical presentation and treatment but different histopathological changes
  4. Associated with mild complaints of Localized pain or discomfort. It can also be called Erythro leukoplakia or Speckled Leukoplakia, and Verrucous Leukoplakia also comes under this. Histopathological Features: Presence or absence of Epithelial Dysplasia. Epithelial Hyperplasia, Surface hyperkeratosis

Oral leukoplakia is an oral potentially malignant disorder (OPMD) that presents as white patches of the oral mucosa. According to the World Health Organization, the term leukoplakia should be reserved for white plaques of questionable risk, having excluded other known diseases or disorders that carry no increased risk for cancer [ 1 ] Leukoplakia is a predominantly white lesion of the oral mucosa than cannot be clinicopathologically characterized as any other definable lesion. The term leukoplakia is a clinical descriptor only and should not be used once histological information is available

OBJECTIVE: Oral leukoplakia has mixed and differing histopathological features, and it is thus difficult to reach an accurate histological diagnosis of oral leukoplakia based on a local biopsy alone. We recently demonstrated the significance of CD163+ macrophages in oral carcinogenesis Although their prevalence is low, homogeneous erythroplakia and speckled leukoplakia present histopathological features ranging from epithelial dysplasia to invasive carcinoma. This justifies placing these lesions among the oral lesions with the highest malignant potential To analyse the clinical and histopathological features of oral leukoplakia (OL) in the Sudan, and to identify the risk factors associated with dysplastic and malignant changes. Methods Records of 117 cases with the diagnosis of OL at the Department of Oral Pathology in the period from 2010 to 2017 were reviewed He/she may also decide the staging of the leukoplakia depending on its size, clinical presentation, histopathological features and the site of the lesion, i.e., on which surface of the oral cavity/mouth, it is present. After a clinical diagnosis is made, biopsy is performed and the confirmatory diagnosis is made

Association between histopathological features of

1.1. Definition, epidemiology, and etiology of oral leukoplakias. In a recently published paper, leukoplakia has been defined as ''a white plaque of questionable risk having excluded (other) known diseases or disorders that carry no increased risk for cancer [].Nevertheless, the most used definition of leukoplakia is still the one proposed by the World Health Organization (WHO) in 1978. Aims and Objectives: The aim of this study was to establish a possible correlation between clinical types of leukoplakia with their histopathological features of high-risk human papillomavirus (HPV) infection and the presence or absence of HPV and expression of p53through immunohistochemistry (IHC) - Clinical and histopathological features of oral erythroplakia and leukoplakia cases at the service of oral diagnosis of UFRN (2000-2012) The most frequent lesion was leukoplakia, mostly affecting the lower lip mucosa followed by the buccal mucosa Background: Increased expression of microRNAs (miRNAs), miR-21, miR-345, and miR-181b has been demonstrated in oral leukoplakia (OL) that progresses to oral squamous cell carcinoma (OSCC), suggesting a miRNA signature with potential prognostic value. On the basis of these findings, this pilot study aimed to investigate the cytological and histopathological features that are used to grade oral. Learn the causes of leukoplakia and how it can affect the mouth and tongue

Histopathological study of leukoplakia allows the clinician: 1.- to exclude any other definable lesions; and 2.- to establish the degree of epithelial dysplasia, if present. It may be hazardous to just observe a white lesion without having taken a biopsy pathological features and Borgna et al. referred to the histopa-thology of conventional PVL.4 suggesting that PVL does have specific histopathological features. Is this actually the case? The Hansen grading system Hansen et al.1 graded the histologic findings of their patients from 1 to 10 depending on severity, although not all the histo To perform an epidemiological survey comparing the cell proliferative activity of 107 cases of oral leukoplakia with their clinical and histopathological characteristics. A cross-sectional, observational, and histological-histochemical study. The cases came from the Histopathological Diagnostic Service of UPF/RS and the School of Dentistry of Araçatuba FOA/UNESP/SP (1986-2016) Histopathological features of oral leukoplakia. In biopsies of OL a distinction can be made histopathologically between dysplastic and non-dysplastic lesions. The assessment and severity of dysplasia is based on architectural disturbance accompanied by cytological atypia gesting leukoplakia. The biopsy specimen should be taken from areas of erythema, induration or erosion, if present.7 Histopathological features of OL may vary from squa-mous hyperplasia unaccompanied by dysplasia to mild, moderate or severe dysplasia. The presence of dyspla-sia is considered to be the most important risk facto

Leukoplakia - an overview ScienceDirect Topic

  1. Laryngeal leukoplakia mostly occurs at the vocal fold, also as known as the vocal fold leukoplakia. The vocal fold leukoplakia has a malignant transformation tendency and the histopathological features include squamous hyperplasia, mild dysplasia, moderate dysplasia, severe dysplasia, and carcinoma in situ. Its occurrence and development are.
  2. However, histopathological features per se are not sufficient to establish the diagnosis; clinical features combined with histopathological changes establish the diagnosis. [2] It is well established that all leukoplakias do not progress to cancer, but they have a higher risk of malignant transformation unless diagnosed early and treated
  3. ology oral verrucous hyperplasia should be used to denote the mass-type lesions both clinically and histologically
  4. Oral leukoplakia has mixed and differing histopathological features, and it is thus difficult to reach an accurate histological diagnosis of oral leukoplakia based on a local biopsy alone. We recently demonstrated the significance of CD163 + macrophages in oral carcinogenesis
  5. A clinical staging system for oral leukoplakia (OL system) on the lines of TNM staging was recommended by WHO in 2005 taking into account the size (L) and the histopathological features (P) of the lesion. (L - Size of leukoplakia) L1 -Size of leukoplakia is . 2cm L2 - Size of leukoplakia is 2 - 4 cm. L3 - Size of leukoplakia is >4c
  6. Proliferative Verrucous Leukoplakia - A Recalcitrant. Aesha Imran. INTRODUCTIONThe term leukoplakia was first used by Schwimmer in 1877 to describe a white lesion of the tongue, which probably represented a syphilitic glossitis. 1 Type of leukoplakia, OPVL was first described by Hansen. It is a long-term progressive condition, which develops.

Objective: Oral leukoplakia has mixed and differing histopathological features, and it is thus difficult to reach an accurate histological diagnosis of oral leukoplakia based on a local biopsy alone. We recently demonstrated the significance of CD163+ mac-rophages in oral carcinogenesis. Herein we sought to determine whether CD163 The histopathological picture of the condition shows five major features: due to which it is assumed that the basal cell layer is not involved in hairy leukoplakia. Although the above features indicate hairy leukoplakia, none of the above histologic features is typical and found only in this lesion. Therefore, the definitive diagnosis of. Thiago Fonseca‐Silva, Marina G Diniz, Sílvia F Sousa, Ricardo S Gomez, Carolina C Gomes, Association between histopathological features of dysplasia in oral leukoplakia and loss of heterozygosity, Histopathology, 10.1111/his.12746, 68, 3, (456-460), (2015)

Oral leukoplakia in the Sudan: clinicopathological

Hairy leukoplakia can be diagnosed either by a histologic examination of a biopsy specimen retrieved from the tongue, or by a cytologic examination of superficial cells [11]. As far as histopathological features are concerned, the most typical findings in patients with hairy leukoplakia include the following 5 characteristics [12] Oral leukoplakia is a white patch or plaque that develops in the oral cavity. The condition is potentially malignant and is strongly associated with tobacco use. When the irritant persists further, the epithelium shows features of cellular degeneration, a well-characterized feature of adaptation The main histopathological changes seen are

Histopathology, Biology and Markers - The Oral Cancer

Leukoplakia and erythroplakia are the most common OPMDs, while special emphasis has been placed on the premalignant nature of oral lichen planus (OLP) . It is generally accepted that the histopathological features of a given lesion, especially the presence and degree of epithelial dysplasia,. Histopathological examination: Histopathological features revealed (Figures 4, 5 above), atypical mitotic figures and keratin pearls, suggesting moderately differentiated squamous cell carcinoma. Discussion: Oral Squamous cell carcinoma is the most common cancer of the head and neck, and many of these are believed to develop from antecedent dysplastic oral mucosal lesions. 5 Leukoplakia is a. The concept of a two-step process of cancer development in the oral mucosa, i.e., the initial presence of a precursor subsequently developing into cancer, is well-established.Oral leukoplakia is the best-known precursor lesion. The evidence that oral leukoplakias are pre-malignant is mainly derived from follow-up studies showing that between < 1 and 18% of oral pre-malignant lesions will. Abstract. Oral proliferative verrucous leukoplakia (OPVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al, it is characterized by a distinct clinical form and defined by its progressive clinical course, changing clinical and histopathological features, and potential to develop into cancer usually higher than 70%

Video: Leukoplakia - SlideShar

[Clinical and histopathological characterization of oral

second one had additional features of induration, erythematous periphery, and feeling of soreness. These are perhaps the salient features that distinguishes the stable speckled leukoplakia from the one that is undergoing transformation into malignancy. It has been stated that speckled leukoplakia is frequently associated with candida albicans. Oral leukoplakia (OL) is a white patch or plaque that cannot be rubbed off, cannot be characterized clinically or histologically as any other condition, and is not associated with any physical or chemical causative agent except tobacco or areca nut. Therefore, a process of exclusion establishes the diagnosis of the disease. In general, the term leukoplakia implies only the clinical feature of. However, histopathological assessment alone does not provide an accurate assessment of MT risk, and other features, such as clinical and molecular parameters, must be taken into account. Oral leukoplakia represents the most common PMD

  1. of clinical and histopathological features (2). PVL RESULTS: All patients were women, above 50 years of affects multiples sites of the oral mucosa, is resistant age, 91.7% were non-smoker and 100% were non-habitual to the available treatment modalities; and show high drinker
  2. This report describes a case of proliferative verrucous leukoplakia (PVL) of the gingiva with no discernible aetiology, which presented in a 36-year-old female. The initial nonscrapable gingival lesion was treated with CO<sub>2</sub> laser ablation, and the histopathological evaluation was carried out. The presence of koilocytic cells in the superficial epithelium led to immunohistochemical.
  3. Oral leukoplakia lesions were the most prevalent (0.65%) and oral erythroplakia showed greater association with malignancy in the histopathological presentation (p = 0.001). Most lesions showed no symptoms (p = 0.004). The most frequent was oral leukoplakia in smoking women, with mean age of 57 years
  4. antly white lesion of the oral mucosa that cannot be characterized as any other definable lesion [].It is a clinical term and it is recommended that a histological report should always include a statement on the presence or absence of ED, along with assessment of its severity [].ED is more or less correlating with a clinical nonhomogeneous.
  5. OBJECTIVE We aimed to characterize proliferative verrucous leukoplakia (PVL) from a clinical and histopathological standpoint and suggest an updated classification. SUBJECTS AND METHODS Records of patients seen at three oral medicine centers with a clinical diagnosis of PVL were reviewed for clinical and histopathological features and malignant.

The histopathology of proliferative verrucous leukoplakia

Histopathological features Histological appearance of oral leukoplakia varies between no dysplasia and carcinoma. Bartholin's cyst Kraurosis vulvae Vestibular papillomatosis Vulvitis Vulvodynia. It can be used for mass screening campaigns. This content does not have an English version Leukoplakia is a Greek term that means white plaque. It presents as a white patch on the epithelium indicating keratin that cannot be scraped easily. It is a nonspecific clinical term and represents a wide variety of lesions without taking into account any etiological and histopathological features Candidal Leukoplakia Clinical features Lesion: Firm, white leathery plaques Site: Cheeks, lips, palate, tongue Diagnosis: PAS (Periodic Acid Schiff) +. Histopathological features Epithelial proliferation (inflammatory/ reactive changes in epithelium) Epithelial Dysplasia Hyphae in leukoplakic lesions 26

Oral Leukoplakia Clinical Presentation: History, Physical

histopathological features of oral epithelial dysplasia and guides the pathologist on diagnosis and key prognostic factors. & 2005 Published by Elsevier Ltd. leukoplakia, with very thick keratin buildup on the surface of the hard palate, often stained dark brown by the tobacco. This 'reverse smoking' i Oral leukoplakia (OL) is a white patch or plaque that cannot be rubbed off, cannot be characterized clinically or histologically as any other condition, and is not associated with any physical or chemical causative agent except tobacco. Therefore, a process of exclusion establishes the diagnosis of the disease Oral hairy leukoplakia may occur when CD4 counts are 200-300 cells/µL or lower. [ 27] Next: Procedures. Procedures. It is important to differentiate hairy leukoplakia from other, more serious, oral lesions that may have a similar clinical appearance. In some cases, biopsy and histologic examination are required to exclude cancer Leukoplakia: Def: A predominantly white lesion of the oral mucosa that cannot be characterized as any other definable lesion. Examples White lesions : candidal leukoplakia, Hairy leukoplakia, tobacco induced lesion, Idiopathic leukoplakia. Age/gender: Above 30 yrs of age, occurs more in males. Etiology: Betel Quid Alcohol Physical irritants Candida albicans - candidial leukoplakia shows more.

Oral Leukoplakia: Clinical, Histopathologic, and Molecular

Leukoplakia is a common condition characterized by an increased risk for malignant transformation. Histopathology of leukoplakia can disclose hyperkeratosis with dysplasia or carcinoma or hyperkeratosis or parakeratosis without dysplasia. Treatment depends on demographic, social, clinical, and histopathologic factors Background . The behavior and prognosis of oral squamous cell carcinoma (OSCC) is presumably different in patients with oral submucous fibrosis (OSF). The objective of this study was to assess the effects of demographic features, habits, and histopathological features in the transformation of OSF to OSCC. Methods . Data were extracted from the archives and histopathological evaluation and.

Vulvar leukoplakia: therapeutic option

However, histopathological assessment alone does in 13.6% to 36.4% of cases [6, 10], and the annual MT rate not provide an accurate assessment of MT risk, and other has been variably reported from 1 to 3% for all leukoplakia features, such as clinical and molecular parameters, must be [6, 7, 10, 11] Note: In spite of diverse and even more recently published definitions for oral leukoplakia, the most widely known is still the one proposed by World Health Organization (WHO) in 1978, which states that leukoplakia is a predominantly white patch that cannot be characterized clinically or histopathologically as any other definable lesion (Kramer et al., 1978; WHO, 2005) Objective: We aimed to characterize proliferative verrucous leukoplakia (PVL) from a clinical and histopathological standpoint and suggest an updated classification. Subjects and Methods: Records of patients seen at three oral medicine centers with a clinical diagnosis of PVL were reviewed for clinical and histopathological features and.

Leukoplakia Leukokeratosi

Background: Oral hairy leukoplakia (OHL) is a greyish white keratotic lesion occurring unilaterally or bilaterally on the lateral border or ventral surface of the tongue and occasionally at other mucosal sites. Aims: The clinical and histopathological features of OHL are only sufficient to reach a presumptive diagnosis. Definitive diagnosis. Definition Leukoplakia is a clinical term, and the lesion is defined as awhite patch or plaque, firmly attached to the oral mucosa, that cannot be classified as any other disease entity. It is a precancerous lesion. Etiology The exact etiology remains unknown. Tobacco, alcohol, chronic local friction, and Candida albicans are important predisposing factors Medical measures that lessen the size, extent or histopathological features of dysplasia within leukoplakia likewise presently do not seem to be of particular promise, as relapse or later malignant transformation can occur, and there is a risk of adverse effects, particularly with systemic agents (which themselves may be contra-indicated in. Histopathological grading showed 40% of leukoplakia cases with mild dysplasia, 2% cases with moderate dysplasia and 58% without any dysplastic features. Among the types of Leukoplakia, 39 cases (78%) were homogenous and 11 cases (22%) were non homogenous. Out o

Hairy Leukoplakia - Pictures, Treatment, Diagnosis, Features

Histopathological grading showed 40% of leukoplakia cases with mild dysplasia, 2% cases with moderate dysplasia and 58% without any dysplastic features. Among the types of Leukoplakia, 39 cases (78%) were homogenous and 11 cases (22%) were non homogenous In addition to defining leukoplakia, this review also establishes a differential diagnosis with the other most important oral diseases and analyzes the different clinical, histologic, and molecular features that can provide an indication of the risk of malignant transformation Conclusion: Oral leukoplakia and erythroplakia can demonstrate a wide spectrum of histopathological features ranging from hyperkeratosis, dysplasia to SCC. Introduction Leukoplakia and erythroplakia are the two prevalent oral potentially malignant disorders (OPMDs). OPMDs include both premalignant lesions and conditions, which shows highe Leukoplakia was defined as a white patch or plaque that cannot be characterised clinically or Pathologically as any other disease. identification and if possible elimination of the suspected etiological factors and in the case of persistent lesions,histopathological examinations. Idiopathic Leukoplakia Galvanism. CLINICAL FEATURES

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